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Model-based dose finding under model uncertainty using general parametric models
Model-based model uncertainty parametric models
2013/6/13
Statistical methodology for the design and analysis of clinical Phase II dose response studies, with related software implementation, are well developed for the case of a normally distributed, homosce...
Threshold estimation based on a p-value framework in dose-response and regression settings
estimation based p-value framework dose-response regression settings
2011/7/5
We use p-values to identify the threshold level at which a regression function takes off from its baseline value, a problem motivated by applications in toxicological and pharmacological dose-response...
Optimal designs for dose-finding experiments in toxicity studies
dose-finding experiment locally c-optimal design multiple-objective design robustoptimal design Weibull model
2010/3/18
We construct optimal designs for estimating fetal malformation rate, prenatal death rate and
an overall toxicity index in a toxicology study under a broad range of model assumptions. We
use Weibull ...