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A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Preventive medicine SARS-CoV-2 Viral infection
2020/6/11
An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally. Countermeasures are needed to treat and prevent ...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A–deficient children from the Republic of the Marshall Islands
retinol retinol binding protein RBP
2016/6/13
Serum retinol is transported by retinol binding protein
(RBP), which has one high-affinity binding site for retinol;
consequently, the molar ratio of retinol to RBP in the circulation
is 1 to 1. In...
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
Retinol binding protein transthyretin retinol retinyl esters
2016/5/31
Two German sisters aged 14 and 17 y were admitted
to the Tübingen eye hospital with a history of night blindness.
In both siblings, plasma retinol binding protein (RBP) concentrations
were below th...
Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?
retinyl esters retinoic acid
2016/5/31
Biesalski et al (1) present a novel case of 2 sisters aged 14 and
17 y with very low plasma retinol concentrations (0.19 mmol/L)
and plasma concentrations of retinol binding protein (RBP) below
the...
Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese men
Retinol-binding protein 4 overfeeding adiposity status young men insulin resistance
2008/12/17
Background: Retinol-binding protein 4 (RBP4) is a novel adipokine that induces insulin resistance in mice. Studies in humans have shown a correlation between serum RBP4 and insulin resistance in obese...
Sex-specific association of fatty acid binding protein 2 and microsomal triacylglycerol transfer protein variants with response to dietary lipid changes in the 3-mo Medi-RIVAGE primary intervention study
Serum lipids dietary fats fatty acid binding protein 2 FABP2 polymorphism microsomal triacylglycerol transfer protein
2008/12/17
Background: The dietary guidelines targeted at reducing cardiovascular risk lead to largely heterogeneous responses in which genetic determinants are largely involved.Objectives: We evaluated the effe...
Potential host-defense role of a human milk vitamin B-12–binding protein, haptocorrin, in the gastrointestinal tract of breastfed infants, as assessed with porcine haptocorrin in vitro
breast milk breastfed infants breastfeeding
2017/1/3
Limited information exists on the biological role of a vitamin B-12–binding protein, haptocorrin, in human milk. The expression of haptocorrin by human mammary epithelial cells and its presence in hum...
Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus
Sex hormone binding globulin anorexia nervosa kwashiorkor marasmus malnutrition inflammation renal failure insulin-like growth factor I insulin
2016/12/19
Background: Customary blood protein markers for malnutrition are of limited value in the diagnosis of protein-energy malnutrition or anorexia nervosa in children and in the follow-up to refeeding...
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km):relevance to genetic disease and polymorphisms
Genetic disease therapeutic vitamin use binding defect favism alcohol intolerance autism migraine headaches single nucleotide polymorphisms enzyme mutations review
2016/12/17
As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or Km, (decreased binding affinity) for a coenzyme, resulting in a lower rate of ...
Effect of vitamin A status at the end of term pregnancy on the saturation of retinol binding protein with retinol
Retinol human pregnancy retinol binding protein RBP transthyretin b-carotene vitamin E placenta
2016/6/3
Background: Vitamin A (retinol), which is required for normal
fetal development and successful gestation, circulates in the
blood bound to a specific protein, the retinol binding protein
(RBP). Lit...