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中国科学院兰州化物所等在CO、CO2催化羰基化利用制备高值非对称脲研究中获进展（图）
催化 反应 药物
2024/11/23
非对称脲类化合物可与蛋白形成多个稳定的氢键。含脲官能团的药物与靶点相互作用，具有独特的生物活性，在药物发展方面和药物化学领域具有重要作用。当前，工业上脲类化合物合成主要采用光气法。连接在同一羰基位点的含氮片段不同，需要利用光气法分步将胺组装到羰基上。通过涉及CO与氯气反应生成剧毒光气，利用一种胺与光气发生反应，生成所需的异氰酸酯中间体/酰氯，而异氰酸酯/酰氯与另一种胺后续反应生成非对称脲衍生物，且...
光热治疗(Photothermal therapy，PTT)作为一种肿瘤光学治疗策略，通过将光能转化为热能，可以有针对性地在局部杀死癌细胞，在恶性肿瘤治疗方面具有微创、长效、安全等特点，受到科研人员的广泛关注。然而强激光（局部温度到达50℃）在破坏肿瘤的同时可能导致肿瘤附近正常器官被灼伤。控制治疗温度不会引起正常组织损伤但治疗效果不理想。如何实现较低温度下（小于42℃）进行光热治疗(Mild-te...
研究果酸联合胶原蛋白敷料，CO 2点阵激光（CO 2 FL）治疗皮肤溃疡切口性骨折痕迹的临床疗效。方法：将我院2016年4月至2017年4月收治的98例面部皮肤上的微小凹陷性骨折痕迹患者随机分为研究组（49例）和替代（49例），置换均给予CO 2 FL，胶原蛋白敷料治疗，研究组加用果酸治疗，比较减少治疗4个疗程后的疗效，温哥华瘢痕量表（VSS）评分，误工期，患者满意度等情况。
Using Continuing Professional Development to Create Meaningful Co-Curricular Learning Opportunities for all Student Pharmacists
Continuing Professional Development
2018/11/22
Objective. To illustrate a method for integrating co-curricular activities, quantify co-curricular activities, and evaluate student perception of achievement of goals.
Methods. Throughout a longitudi...
10例 60 Co源辐射事故受照者眼晶状体的随访观察
远期效应 眼晶状体浑浊 医学随访
2016/1/7
观察 60Co源辐射事故对受照者眼晶状体的远后效应。方法 对河南省1986年至2000年期间发生的4起60Co源辐射事故共10例受照者进行眼晶状体远期医学观察。用复方托吡卡胺充分散瞳后在裂隙灯下检查眼晶状体,记录病变特征。结果 开封事故中"亮"、新乡事故中"梅"分别于照后2、3年出现典型放射性白内障;许昌事故中"许",照后6年出现典型放射性白内障;开封事故中"燕"、郑州事故中"杰"、新乡事故中"天...
Psychological Co morbidity in Children and Adolescents with Learning Disorders
learning disorder comorbidity
2015/7/31
Schools play a crucial and formative role in the spheres of cognitive, language, emotional, social and moral development of a child (Kapur, 1995). Academic skills such as reading, writing and mathemat...
Impact Of Hepatitis C Co-Infection On CD4 Cell Count In HIV Infected Subjects
Hepatitis C Human Immunodeficiency virus CD4 cell count Co-infection
2015/7/28
Background: Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) co-infection is reported to be common among HIV infected subjects due to share routes of transmission. The fact that HCV infe...
The effect of carbohydrate and marine peptide hydrolysate co-ingestion on endurance exercise metabolism and performance
Marine peptide Hydrolyzed protein Exercise metabolism
2015/7/27
The purpose of this study was to examine the efficacy of introducing a fish protein hydrolysate (PEP) concurrently with carbohydrate (CHO) and whey protein (PRO) on endurance exercise metabolism and p...
Unusual Large Sporadic Angiomyolipoma Co-existing with Huge Simple Renal Cyst
Renal Angiomyolipoma Sporadic AML Simple renal cyst
2015/7/21
Renal Angiomyolipoma (AML) is an unusual benign mesenchymal tumor with no malignant potential. It is composed of adipose tissue, smooth muscle and abnormal thick walled blood vessels. It can occur spo...
Co-Variations among Cognition, Cerebellar Disorders and Cortical Areas With Regional Glucose-Metabolic Activities in a Homogeneous Sample with Uner Tan Syndrome: Holistic Functioning of the Human Brain
Uner Tan syndrome ataxia intelligence neural network holistic brain
2015/6/10
Patients with Uner Tan syndrome (UTS) exhibit habitual quadrupedal locomotion (QL), intellectual disability, dysarthric speech and truncal ataxia. Examination of cognitive ability in this syndrome has...
The Psycho-oncology Co-operative Research Group
The Psycho-oncology Co-operative Research Group
2015/3/19
The Psycho-oncology Co-operative Research Group was conceived in response to the recognised need to develop the capacity and coordinated collaboration to conduct large-scale, multi-centre psycho-oncol...
Co-operative Clinical Trials in Cancer – the need for increased capacity
increased capacity Cancer
2015/1/23
In the clinical management of cancer, the
practice of evidence based medicine is
almost totally reliant on the findings of
previous clinical trials
Effects of Losartan and Vanillic Acid Co-Administration on Ischemia-Reperfusion-Induced Oxidative Stress in Isolated Rat Heart
Oxidative Stress Injury Vanillic Acid Losartan
2015/10/13
Background: Experimental studies have demonstrated that angiotensin II (ANG-II)-induced oxidative stress contributes to the pathogenesis of I/R injury.
基于COⅠ基因的媒介蝇类快速分子鉴定研究
细胞色素C氧化酶亚基Ⅰ基因 蝇类 分类鉴定
2014/10/30
为解决蝇类形态学鉴定的不足,建立基于细胞色素C氧化酶亚基Ⅰ(COⅠ)基因的DNA条形码技术对蝇类进行分子鉴定。方法 选取烟台口岸常见的16只蝇类作为研究对象,形态学鉴定后,取蝇的单后足代表微量组织,提取总DNA。依据资料,选取COⅠ国际通用引物LCO1490:5′-GGT CAA CAA ATC ATA AAG ATA TTG G-3′,HCO2198:5′-TAA ACT TCA GGG TGA...