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新冠病毒持续变异,目前在人群中流行的主要的奥密克戎及其变体,由于其在刺突蛋白(Spike S)上的突变众多,对既往感染者或者疫苗接种者血清的中和抗体产生了严重的免疫逃逸,处于临床阶段的新冠中和抗体药物对Omicron突变株活性也大大降低。因此,亟需开发出新的中和抗体,为当前新冠肺炎疫情的防治提供药物储备。
新型冠状病毒(SARS-CoV-2)引起的全球COVID-19爆发严重威胁人类健康。 SARS-CoV-2具有多器官嗜性,可引起发烧,咳嗽,严重的呼吸道疾病和多器官衰竭。宿主细胞受体是病毒嗜性和引发疾病的关键决定因素。但目前为止,被广泛认可的SARS-CoV-2受体仅有ACE2。而ACE2的表达相对局限在胃肠道、肾脏、心脏等器官,难以解释SARS-CoV-2的多器官嗜性。另外,SARS-CoV和S...
新冠病毒(SARS-CoV-2)利用其刺突(spike)蛋白识别宿主细胞受体(如ACE2),引起spike中的S1与S2结构域分离,触发S2结构域的构象改变,最终导致病毒与宿主细胞膜融合从而完成病毒入侵。但是,目前结构生物学研究发现新冠病毒spike结合ACE2受体时仅RBD结构域存在较大构象改变,其它部分只发生了细微的变化,并不足以触发紧密结合的S1和S2结构域分离。因此,新冠病毒spike结合...
The Gordon Research Seminar on Cellular and Molecular Mechanisms of Toxicity is a unique forum for graduate students, postdocs, and other early career scientists to present and exchange novel, cutting...
Portland State University researchers have found that only about half the genes in a specific virus affecting single cell organisms is needed to infect a host. This means the virus can undergo major m...
The Gordon Research Seminar on Viruses and Cells is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new...
The 2017 Viruses and Cells GRC, the premier conference in the field of virology, will cover seminal topics in virology ranging from viral entry and structure to virus-host interactions, viral replicat...
The 2017 meeting has two main goals. The first goal is to broaden the scope beyond DBP formation within conventional drinking water plants. Disinfection represents a balance between controlling the ac...
The inception of the GRC on Physical Virology in 2009 was born of the desire to bring together scientists with an interest in applying a multidisciplinary approach that includes biology, biophysics, c...
Mycotoxins and Phycotoxins are diverse and highly toxic compounds that naturally occur in the environment and frequently contaminate food, feeds and water on every continent. Climatic conditions are s...
The 2017 Staphylococcal Diseases Gordon Research Conference (GRC) and its associated Gordon Research Seminar (GRS) will be held at Waterville Valley, New Hampshire, USA with the GRS being held on Augu...
Cold Spring Harbor Laboratory (CSHL) is pleased to announce the sixth meeting on the history of science organized by the Laboratory's Genentech Center for the History of Molecular Biology and Biotechn...
The National Science Foundation (NSF) has issued a letter to the scientific community inviting proposals for rapid response grants for investigations related to Ebola. NSF seeks proposals for basic re...
The National Science Foundation (NSF) has issued a letter to the scientific community inviting proposals for rapid response grants for investigations related to Ebola. NSF seeks proposals for basic re...
Papilloma virus infections and superbug tuberculosis strains will come under renewed attack, after the federal government today agreed to support two University of Queensland research projects.

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