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PTEN是一个关键的抑癌基因，其蛋白在肿瘤中经常发生缺失。PTEN蛋白的缺失可由遗传学和表观遗传学因素导致，但在肿瘤中PTEN蛋白的缺失比例常常比其基因突变、缺失比例要高很多，因此PTEN蛋白的降解成为肿瘤中研究的一个热点问题。以往研究发现，PTEN蛋白可受到多种翻译后修饰并转移到蛋白酶体进行降解，也有少量研究发现PTEN可经由溶酶体途径降解，但PTEN溶酶体降解的具体分子机制尚不清楚。
Forty Years of mRNA Splicing: From Discovery to Therapeutics
Biology of Spliceosome Spliceosome Complexes
2017/4/5
The discovery of mRNA splicing in 1977 established a new step in the central dogma of molecular biology, the “flow” of genetic information from DNA to RNA to protein product. Our meeting will focus on...
An international study that has identified new genetic regions involved in rheumatoid arthritis has shed light on existing medicines that could be effective in treating the disease.