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Time-dependent Changes in Concentration of Two Clinically Used Acetylcholinesterase Reactivators (HI-6 and Obidoxime) in Rat Plasma Determined by HPLC Techniques after in vivo Administration
Time-dependent Changes Clinically Acetylcholinesterase Reactivators HPLC Techniques
2010/9/17
A simple and reliable HPLC method for determination of rat plasma levels of clinically used acetylcholinesterase (AChE) reactivators (HI-6 and obidoxime) is presented in our study. Separation was carr...
摘要 本文基于振动绝热性分析, 用量子散射理论研究I+HI'(v)→IH(v')+I'反应几率的振荡行为, 其中双原子间相互作用势的振动本征态是Morse振子的严格解。在计算反应几率时采用分布高斯基(Distributed Gaussian Basis Sets; DGBS)展于方法, 既保持了反应几率的解析表达式, 又有效地简化了计算。计算结果明显地揭示了反应几率在低碰能区域的振荡行为。对反应机...