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2022年8月5日，美国肝病研究学会期刊HEPATOLOGY《肝病学》在线刊登了中国医学科学院药物研究所李平平课题组和温州医科大学黄志峰课题组发表的题为“Hepatocyte Ltb4r1 promotes NAFLD development in obesity”（肝细胞Ltb4r1促进肥胖型非酒精性脂肪肝发生发展）的研究论文，该研究发现白三烯B4（LTB4）直接引起肝细胞脂质生成，验证LTB4...
非酒精性脂肪肝（NAFLD）是我国第一大慢性肝病，目前尚无获批治疗药物。NAFLD患者肝脏脂质从头合成数倍增加，肝脏脂质含量与NAFLD发展密切相关。花生四烯酸代谢产物白三烯B4（LTB4）在肥胖和NAFLD患者中显著增加。然而，LTB4与其受体Ltb4r1是否促进NAFLD进展尚不清楚。
Effect of Spermidine on Intracellular Calcium Ion Mobilization in Chicken Phagocytes Treated with Leukotriene B4 (LTB4)
spermidine LTB4 calcium ion chicken phagocytes
2009/7/31
The effect of spermidine, a type of polyamine present in exudates from inflamed tissues and bacteria-infected sites in humans, on calcium mobilization of leukotriene B4 (LTB4)-stimulated chicken abdom...
Role of the LTB4/BLT1 Pathway in Allergen-induced Airway Hyperresponsiveness and Inflammation
airway responsiveness cytokines lipid mediators lung inflammation Tcells
2010/11/18
LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory dis...