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Ultrastructural elastic deformation of cortical bone tissue probed by NIR Raman spectroscopy
Raman bone biomechanics
2014/11/6
Raman spectroscopy is used as a probe of ultrastructural (molecular) changes in both the mineral and matrix (protein and glycoprotein, predominantly type I collagen) components of murine cortical bone...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
2014/11/6
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...
Exercise Alters Mineral and Matrix Composition in the Absence of Adding New Bone
Mechanical loading Mechanical properties Mineral Collagen Raman spectroscopy
2014/11/6
The mechanical properties of bone are dictated by its amount, distribution and ‘quality’. The composition of the mineral and matrix phases is integral to defining ‘bone quality’. Exercise can potentia...
Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice
inbred mice mech anical properties mCT PCR Raman histomorphometry
2014/11/6
Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist...
Applications of atomic force microscopy for the assessment of nanoscale morphological and mechanical properties of bone
Atomic Force Microscopy Scanning probe microscopy
2014/11/6
Scanning probe microscopy (SPM) has been in use for 30 years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolu...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Microcomputed Tomography Applications in Bone and Mineral Research
Bone CT Mineralization Vascularization BMD Modeling
2014/11/6
Microcomputed tomography (μCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics. Commercially available sy...
"Development and Testing of Optic Probes for Transcutaneous Raman Spectroscopy Bone Diagnostic"
Optic Probes Transcutaneous Raman Spectroscopy Bone Diagnostic
2009/12/17
This project is for the development and testing of optic probes to be used in a novel biomedical imaging device for bone diagnostics. The fundamental technology, Transcutaneous Raman Spectroscopy (TRS...
Review of "The Physical Measurement of Bone", Edited by C.M. Langton and C.F. Njeh
The Physical Measurement of Bone C.M. Langton C.F. Njeh
2010/3/1
This book is intended for biologists, medical physicists, biomechanical engineers and clinicians who are involved in bone studies. For these practitioners, the book is a comprehensive review of physic...