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Dissecting the expression landscape of RNA-binding proteins in human cancers
RNA-binding proteins cancer pathogenesis
2015/3/5
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by controlling gene expression at the post-transcriptional level. Results We explore the expression of more than 800...
Calcium Integrin Binding Protein Associates with Integrins αVβ3 and αIIbβ3 Independent of β3 Activation Motifs
Leukocyte lntegrin Cytoskeleton Hematopoietic Activation Signaling
2013/1/29
The Calcium Integrin Binding protein (CIB) has been identified as interacting specifically with the cytoplasmic tail of the integrin αIIb domain to induce receptor activation and integrin αIIbβ3 media...
A predictive method for the evaluation of peptide binding in pocket 1 of HLA-DR1 via global minimization of energy interactions.
predictive method peptide binding global minimization of energy interactions
2009/12/24
A predictive method for the evaluation of peptide binding in pocket 1 of HLA-DR1 via global minimization of energy interactions.
Analysis of metal ion binding to DNA in regulating metallothionein-IIA gene expression
metallothionein metal responsive elements metal ions binding DNA bending
2009/4/1
The mammalian metallothioneins (MT) are effectively induced in response to the various heavy metal ions. The inductions of these genes are mainly based on the transcriptional activation and the metal ...
Identification of copper-binding nuclear proteins in mouse brain: its involvement in retinoic acid receptor signaling
copper-binding nuclear proteins mouse brain retinoic acid receptor signaling
2009/4/1
Copper is an essential micronutrient with numerous cellular functions. Previous studies have demonstrated that copper deficiency in P19 embryonal carcinoma cells by using a copper depletor, bathocupro...
Copper Binding of Nuclear RNA- and DNA-Binding Proteins p54nrb/NonO and PSF
copper p54nrb/Non-POU-domain-containing octamer binding protein (p54nrb/NonO) polypyrimidine tract-binding protein-associated splicing factor (PSF) nucleus
2009/3/23
The biological function of nuclear copper in mammalian cells is poorly understood because little is known about specific binding protein(s) for nuclear copper. We recently purified that p54nrb/Non-POU...
Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase(renin binding protein)
nucleotide binding properties N-acetyl-D-glucosamine 2-epimerase(renin binding protein)
2009/3/2
Our recent studies have demonstrated that the middle domain of N-acetyl-D-glucosamine (GlcNAc) 2-epimerase participates in the specificity for and binding of nucleotides. To identify the residue con...
Geldanamycin, a heat-shock protein 90-binding agent, induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol 13-acetate
Geldanamycin heat-shock protein 90-binding agent destabilization of Lck 12-O-tetradecanoylphorbol 13-acetate
2009/3/2
Geldanamycin, a heat-shock protein 90 (Hsp90)-binding agent, modulates various cellular activities. The present study found that, although geldanamycin by itself had no effect on thymocyte viability...
Effect of Electrostatic Interactions on Binding and Retention of DNA Oligomers to PNA Liposomes Assessed by FRET Measurements
Peptide nucleic acid(PNA) Liposome DNA adsorption Biosensors FRET
2009/12/22
The FRET signal was maintained in the presence of 10-,20-,40-,
and 60-mer DNA inhighionic-strength buffer,showing that the driving force for the desorption is electrostatic repulsion between the boun...
Sequence-Specific Binding of DNA to Liposomes Containing di-Alkyl Peptide Nucleic Acid (PNA) Amphiphiles
Sequence-Specific Binding DNA Liposomes Containing di-Alkyl Peptide Nucleic Acid
2009/12/22
Sequence-Specific Binding of DNA to Liposomes Containing di-Alkyl Peptide Nucleic Acid (PNA) Amphiphiles.