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首次发现胚胎发育中眼睑闭合调控机制——华南理工大学医学院王键教授团队研究成果以封面文章发表在Science Signaling（图）
胚胎发育 中眼睑闭合 调控机制 王键 教授 研究成果 封面文章 Science Signaling
2018/11/7
近日，华南理工大学医学院王键教授带领的神经生物学团队在世界上首次发现胚胎发育中眼睑闭合的调控机制，相关成果以“Sphingosine 1-phosphate stimulates eyelid closure in the develop rat by stimulating EGFR signaling”为题，在Science Signaling以封面文章发表。在胚胎发育的过程中，眼睑需要闭合以...
P53 “master switch” remains top target in gene signaling network controlling cancer suppression（图）
P53 master switch top target gene signaling network controlling cancer suppression
2017/10/25
There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
2016冷泉港学术会议：代谢信号机制（Cold Spring Harbor conference on Mechanisms of Metabolic Signaling）
Genetics Genomes
2017/1/19
Metabolic regulation is at the intersection of many scientific fields, ranging from basic biochemistry and molecular biology to physiology, to the study of disease pathogenesis. Currently, a major cha...
2017"Wnt Signaling"戈登学术会议（The 2017 Gordon Research Conference on Wnt Signaling）
Wnt Signaling Stem Cell Control
2017/1/18
The 2017 Gordon Research Conference titled "Wnt Signaling: A Pathway Implicated in Animal Development, Stem Cell Control and Cancer" seeks to advance our understanding of how the highly conserved Wnt ...
2017疾病模式识别信号 Keystone Symposia（2017 Keystone Symposia on Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease）
PRR Signaling Inflammatory Disease
2017/1/13
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary sessio...
Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids
dietary fat tyrosine kinase protein kinase
2016/6/1
Extracellular signals are transmitted to intracellular
targets through many signal-transduction pathways. Each
signaling pathway is composed of a network of interacting signaling
molecules that reg...
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
NMDA receptor BDNF neurotrophins
2015/7/28
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathol...
TRANSGENIC USE OF SMAD7 TO SUPPRESS TGFβ SIGNALING DURING MOUSE DEVELOPMENT
heart development doxycycline inducible
2015/5/25
Neural crest cells (NCC) are a multipotent population of cells that form at the dorsal region of neural tube, migrate and contribute to a vast array of embryonic structures, including the majority of ...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
The effects of CaMKII signaling on neuronal viability
Calcium/calmodulin-dependent protein kinase II CaMKII Neuron Neurotransmitter Neurotoxicity
2015/5/21
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a critical modulator of synaptic function, plasticity, and learning and memory. In neurons and astrocytes, CaMKII regulates cellular excitabi...
Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice
INFLAMMATION MACROPHAGE ACUTE EXERCISE ADIPOSE TISSUE
2017/4/20
Introduction: Adipose tissue insulin action is impaired in obesity and is associated with inflammation, macrophage infiltration, and polarization toward a proinflammatory phenotype. Acute exercise can...
Signaling Pathways Involved in Mechanical Stimulation and ECM Geometry in Bone Cells
Mechanical Stimulation Osteoblast ECM
2015/1/12
The proliferation and differentiation of osteoblasts are influenced by mechanical and geometrical growth environments. A specific aim of my thesis was the elucidation of signaling pathways involved in...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Implications of Ape1 in reactive oxygen signaling response following cisplatin treatment of dorsal root ganglion neurons
ROS APE1 base excision repair neurotoxicity
2014/12/12
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
Ref-1 DNA-binding activity signaling
2014/12/12
The Ref-1 (also called APE or HAP1) protein is a bifunctional enzyme impacting on a wide variety of important cellular functions. It acts as a major member of the DNA base excision repair pathway. Mor...