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Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats
Synergistic actions apomorphine and m-chlorophenylpiperazine rats
2009/5/8
It has been suggested that dopamine (DA) and serotonin (5-HT) and their receptors, particularly D2-like and 5-HT2C receptors, may play a significant role in the control of male sexual function. The ...
The influence of castration on pharmacologically induced penile erection in the cat
Testosterone vasoactive agents cAMP cGMP
2009/2/18
The purpose of this study was to investigate the in vivo effects of intracavernosal injections of adrenomedullin (ADM), calcitonin gene-related peptide (CGRP), nociceptin, vasoactive intestinal po...
Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model
ADM CGRP penile erection nitric oxide KATp channe
2009/2/17
The purpose of the present study was to investigate the effects of intracavernosal injections of adrenomedullin (ADM) and calcitonin gene-related peptide (CGRP), two structurally similar peptides,...
Androgenic regulation of NO availability in rat penile erection
Rats testosterone nitric oxide
2009/2/17
Prior studies from this laboratory, using untreated castrated (CASTRATE) rats and testosterone-treated castrated (TESTO) rats, have shown that the magnitude of the intracavernosal pressure increas...
Suppressive effects of chronic hyperprolactinemia on penile erection and yawning following administration of apomorphine to pituitary-transplanted rats
Prolactin testosterone pituitary transplantation castration
2009/2/17
Recent studies showed in vivo and in vitro that acutely introduced prolactin (PRL) excess was capable of diminishing penile erectile function independently of the LH-testosterone (T) dynamics. In th...
Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathway
Erectile dysfunction impotence priapism Viagra
2008/12/29
Sildenafil, in nanomolar serum levels, is an effective phosphodiesterase type 5 inhibitor, and facilitates penile erection only during sexual stimulation. However, there is limited information on th...
Cavernosus Muscle Contraction During Erection：Is It Voluntary or Reflex, Given the Striated Nature of the Muscles?
Ischio-/bulbo-cavernosus muscle corpora cavernosa intracorporal pressure electromyography
2008/12/24
The bulbo- and ischio-cavernosus muscles (BCM, ICM) contract in the rigid erection phase, leading to a suprasystolic cavernosal pressure. We investigated the hypothesis that the contraction of caver...
Penile Erection During Transurethral Surgery
Endoscopy alpha-adrenergic agonists phenylephrine priapism
2008/12/24
Intraoperative penile erection during endoscopic surgery, although an infrequent occurrence, is a troublesome complication and a challenge to the urologist. It is difficult to perform the procedu...
Erection- and Ejaculation-Preserving Cystectomy With Orthotopic Urinary Diversion：Is It Feasible?
Bladder cancer treatment sexual function prognosis
2008/12/23
Nerve-sparing techniques to preserve sexual function in men undergoing cystoprostatectomy have been documented by different centers. We evaluated the results of the first 4 erection- and ejaculation...
Combination Therapy: Medicated Urethral System for Erection Enhances Sexual Satisfaction in Sildenafil Citrate Failure Following Nerve-Sparing Radical Prostatectomy
Erectile dysfunction MUSE intraurethral alprostadil
2008/12/23
The objective of our study was to assess the effectiveness of combining medicated urethral system for erection (MUSE) with sildenafil citrate in men unsatisfied with the sildenafil alone. Baseline a...
Control of Penile Erection by the Melanocortinergic System：Experimental Evidences and Therapeutic Perspectives
Penile Erection Melanocortinergic System Experimental Evidences Therapeutic Perspectives
2008/12/22
Penile erection is the ultimate vasculo-tissular response to an integrated and complex series of physiological processes elicited by psychological, neural, and hemodynamic events (Giuliano and Rampin,...
Nitric Oxide Regulation of Penile Erection: Biology and Therapeutic Implications
Nitric Oxide Regulation Penile Erection Biology Therapeutic Implications
2008/12/15
For approximately a decade now, substantial evidence has accrued supporting nitric oxide (NO) as the central component of a major signal transduction system that acts in the penis to mediate the erect...
Efficacy of Vardenafil and Sildenafil in Facilitating Penile Erection in an Animal Model
Pelvic nerve-mediated erection intracavernosal pressure
2008/12/3
Vardenafil and sildenafil are potent and specific phosphodiesterase type 5 (PDE 5) inhibitors. In human penile cavernosal smooth muscle cells, we have previously shown that vardenafil has a lower bi...
Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase
Noncholinergic penile erection gene endothelial nitric oxide synthase
2008/12/1
With the current understanding that nitric oxide (NO) mediates penile erection, the endothelial isoform of NO synthase (eNOS) has been implicated in this function. We undertook this study applying t...